O OEt O TBSOTf (cat.) TBS CO2Et O Br TASF 92:8 dr TBS O CO2Et

2014/02/15
TBS
O
OEt
O
O
O TBS
TBSOTf (cat.)
TASF
92:8 dr
CO2Et
CO2Et
TESO
TESO
DIBALH
OSET
NaHMDS
TESCl
Br
CO2Et
TESO
DMP
CO2Me
MeOH (cat.)
quinuclidine (cat.)
OH
CO2Me
O
OH
TESO
TESO
O
NR3
H
CO2Me
OMe
R3N
O
TESO
OH
TESO
O
TBS OTf
CO2Me
CO2Me
OTBS
OH
O
1) TMSOTf
HF·pyr
TMSO
2) IBX·MPO
CO2Me 伊藤・三枝酸化
OTBS
TMSO
[4+2]
TMSCl
CO2Me
OTBS
CO2Me
OTBS
TMSO
O
work up
CO2Me
OTBS
CO2Me
OTBS
CO2Me
OTBS
Diels-Alder
OH
Br
O
Br
Br
OH
OsO4, NMO
N
Ts
Os
NMO
Ⅵ
Os
NaIO4
N
Ts
Ⅷ
N
Ts
OH
O
HO
NTs
OH
NHTs
NTs
NTs
Br
Br
N
Ts
Br
N
Ts
N
Ts
aza-cope rearengement, intramolecular Mannich reaction
PhS PBu3
OH
Bu3P O
NTs
NaBH4
PhSSPh, PBu3
Br
Br
Ph S S Ph
NTs
PhS PBu3
PhS
PBu3
N
Ts
PhS
NTs
PhS
Bu3SnH, AIBN
PhS
N
Ts
NTs
Br
NTs
H
H
Bu3P O Bu3Sn
N
Ts
N
Ts
N
Ts
Bu3Sn H
NC
N N
CN
2
CN
SnBu3
PhS
H SnBu3
SnBu3
PhSH