iPS Cell-based Research Project on Hepatic Toxicity and Metabolism
ܖ๕ܿٳอξΣΛΠ ܈ΉησρͼήρςȜίυΐͿ·Π 教授（兼任） 客員教授 特任教授 特任助教（常勤） 辻川 和丈 寺下 善一 目黒 寛治 神宮司健太郎 Cancer chemical library project Kazutake TSUJIKAWA 06-6879-8190 Zen-ichi TERASHITA 06-6879-4412 Specially Appointed Professor Kenji MEGURO 06-6879-4412 Specially Appointed Assistant Professor Kentaro JINGUSHI 06-6879-8192 [email protected] [email protected] [email protected] [email protected] Professor Visiting Professor 教 授 辻川 和丈 ȁ՛૧ȶ܈ȷ͉࡛ह̦࣭͈ͩঘཌࡔ֦͈ΠΛίͬ ̳͛ͥۛ́ȃ̭͈̽̀͢ͅ܈చ̳ͥခ࢘̈́হၷ͈ ୋࡄ͂ݪȂ̷͈ࡄͅܢ்ͬض଼ݪႉ͒එ̫̭̦ͥ͂ ͈ݪࡄڠਹါ̈́ঀྵ̞̳͂̈́̽̀͘ȃ̷͈̹͉͛ͅȂ ܈ळ༾͈௩Ȃ૫Ȇഢ֊̯͉ͣͅࢯ܈सఛෝͬࢹܥ ֒ഥঊȂΗϋΩ·ৗτασٜ́ྶ̱Ȃ̷͈ͦͣอ࡛͞ܥ ෝͬଷࢄ̧́ͥͬ༎͙̳ࡄ̦ݪ୨བ̯̞̳ͦ̀͘ȃ ུίυΐͿ·Π͉́໐ڠشજड୶ࡄܖݪ๕মުȶا ࣣρͼήρςȜͬڰဥ̱̹൝ड୶ࡄݪȆܖ֗ޗ ๕͈ାȷ̤̞̀ͅȂႉ͈͂ࡄފݪႁͤ͢ͅ܈ႉ ఘͬဥ̞͈̀܈αȜσͬญ̦̱Ȃহၷດഎ͂̈́ͥঊͬ ౝ̱̞̳॑̀͘ȃ̷̹͈͘ດഎঊ͈ܥෝٜͬྶ̱Ȃ̷ ͈ܥෝࣣͬاͬဥ̞̀ଷࢄ̳̭ͥ͂ͬ࿒ঐ̱̹ड୶ ࡄ̳̞̀͛͘ૺͬݪȃ̷͈ͦͤ͢ͅ܈ঊດഎহၷ͈ ْܢഎ֓ȪŧŪųŴŵĮŪůĮŤŭŢŴŴȫȂܡంͅచ̱̀ྶ̈́ږ պͬ̾֓ȪţŦŴŵĮŪůĮŤŭŢŴŴȫͬୋ̱Ȃႉͅ එ̫̭ͥ͂ͬ࿒ঐ̱̳͘ȃ 䛜䜣⣽⬊ ᶆⓗศᏊ䛾Ỵᐃ 䝬䜲䜽䝻䜰䝺䜲 ゎᯒ ABH3䛾 X⥺⤖ᬗ ᵓ㐀ゎᯒ 䜿䝭䜹䝹䝷䜲䝤䝷䝸䞊䜢 ⏝䛔䛯invitro,invivoホ౯ 䛜䜣䛾ศᏊᶆⓗ⒪⸆䛾〇 ड߃͈৽ါა 1. Nakao S. et al., Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett., 24, 1071-4, 14 ܖ๕ܿٳอξΣΛΠ ŪőŔ ۴ඉȆయ৫ίυΐͿ·Π iPS Cell-based Research Project on Hepatic Toxicity and Metabolism 教 授（兼任） 水口 裕之 Professor Hiroyuki MIZUGUCHI 06-6879-8185 特任助教（常勤） 酒井 英子 Specially Appointed Assistant Professor Eiko SAKAI 06-6879-8187 [email protected] [email protected] 教 授 水口 裕之 ȁΪΠ ŪőŔ ळ༾͉۴௫൝͈̜ͣͥ͠ழȆळ༾̳ͅا ̭̥ͥ͂ͣȂ͈ඉບ͞ࠏثठ֓ၷ൝͈͒؊ဥ̦ ܢఞ̯̞ͦ̀ͥȃ̱̥̱̦̈́ͣȂਲြ͈֦סঊȪͼ Πͼϋ൝ȫͥ͢ͅاည൵༹͉́Ȃ۴ळ༾͈͒࢘ا ၚ̦ޭ͛̀೩̞̭̦͂هఴ̞͂̈́̽̀ͥȃِș͉Ȃ۴௫ ͈อͅਹါ̈́֒ഥঊ͈ͬاഐ୨̈́শͅܢ൵ව̳̭ͥ ͂ͤ͢ͅȂ۴ळ༾͈͒ͬاഎͅ௯ૺ̵̯Ȃయ ူΪΠ۴ळ༾ͅഌ̳ͥτασ͈య৫ࣖள͈֒ഥঊ อ࡛τασͬা̳۴ळ༾͈ैୋ଼̱̹ͅȃ ȁِșུ͉۴ळ༾ͬȂ૧ٳอࡄ͈́ݪ၌ဥ̦ܢఞ̯ͦ ͥ ŪůġŷŪŵųŰ ඉບ͞ࠏث۴య৫Ȃࣖளည൵ບͅࠏث၌ဥ ̳̭ͥ͂ͬ࿒എͅȂ̷͈ܖ๕ܿٳอ࣐̞ͬ̽̀ͥȃ̯ ͣͅȂ۴ͼ;σΑࡄ͈͒ݪ؊ဥ͞Ȃ۴ळ༾۾ͅاဓ ̳ͥ֒ഥঊ͈ܥෝٜଢ଼Ȃᦙϸळ༾͞ಸષळ༾൝͈͒ اည൵ܿٳอ൝͈ࡄ̞࣐ͥ̀̽ͬݪȃ ȁոષུ͈̠͉́͢ͅȂঊڠ͈͂Ⴒࠈ͈ ͂͜ȂŪőŔ ळ༾ܿͬߐঀ̱̹ࡄ̤࣐ͤ̀̽ͬݪȂ ུͬ୶൵̧́ͥ૽ऺ଼͈࣐̞֗ͬ̽̀ͥȃ ࡄهݪఴ 1）ヒト iPS 細胞から肝臓細胞への高効率分化誘導法の開発 2）ヒト iPS 細胞由来分化誘導肝細胞を用いた毒性評価・肝代 謝評価・薬効評価系の開発 3）ヒト iPS 細胞から膵臓細胞、小腸細胞等への高効率分化誘 導法の開発と創薬応用に関する研究 ड߃͈৽ါა 1. Nagamoto Y. et al., Efficient engraftment of human iPS cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xL mutant gene. Cell Transplantation, in press. 2. Watanabe H. et al., HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin. PLoS One, 9, e90791 (2014) 3. Takayama K. et al., &&$$7HQKDQFHUELQGLQJSURWHLQPHGLDWHGUHJXODWLRQRI7*)ȕUHFHSWRUH[SUHVVLRQGHWHUPLQHWKHKHSDWREODVWIDWHGHFLVLRQ Development, 141, 91-100 (2014) 4. Takayama K. et al., Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human Laminin 111-coated dishes. Stem Cell Rep., 1，322-335 (2013) 5. Takayama K. et al., 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials, 34, 1781-1789 (2013) 7DND\DPD.HWDO*HQHUDWLRQRIPHWDEROLFDOO\IXQFWLRQLQJKHSDWRF\WHVIURPKXPDQSOXULSRWHQWVWHPFHOOVE\)2;$DQG+1)ĮWUDQVGXFWLRQ J. Hepatol., 57, 628-636 (2012) ܖ๕ܿٳอξΣΛΠ ŪőŔ ෞ૰ࠐඉίυΐͿ·Π 教授（兼任） 橋本 均 特任准教授 中澤 敬信 特任助教 永安 一樹 Professor Specifically Appointed Associate Professor Specifically Appointed Assistant Professor iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology Hitoshi HASHIMOTO 06-6879-8180 Takanobu NAKAZAWA 06-6879-8182 Kazuki NAGAYASU 06-6879-8183 Fax 06-6879-8184 [email protected] [email protected] [email protected] 教 授 橋本 均 ȁΪΠ ŪőŔ ळ༾͈ ै ୋ ܿ ͬ ဥ ̞Ȃ ۛ৪͂࠲ુ৪͈ ŪőŔ ळ༾̷̸ͬͦ ͦෞ૰ࠐळ༾ͅ ̵̯̀اȂอో͞ ૰ࠐܥෝ̳ͬڛ ͥ ̭ ͂ ͅ ͢ ̽ ̀Ȃ ۛ৪͈ෞ̦͈̓͢ ̠̈́։ુͬ̽̀ ̞̥ٜͥͬྶ̳ͥ ௷̦̥ͤͬං̹̞ ఉෝۚळ༾ ȪņŔȆŪőŔȫ ̥͈ͣΓυΠΣϋ૰ࠐळ༾͈͂اا ͂ ࣉ ̢ ̀ ̞ ͘ ̳ȃ ༹̭͈̠༷̈́̽̀͢͢ͅȂୈ૰͈ۛอછࡔ֦͈൳͞ হၷ͈ດഎঊ͈ౝ॑ͬ࿒ঐ̱̳͘ȃ ȁୈ૰͈ۛພ֦̱͂̀Ȃ႕̢͊ఉ̩͈֒ഥ֦ঊ۪͂ޏ ါ֦̦ໝॠͅࡽैဥ̱̀อછ̳ͥب୰̈́̓Ȃఉତ͈ພ ֦ب୰̦া̯̞̳̦ͦ̀͘Ȃબ̯̹͈͉̩ͦ̈́͜Ȃ ̷͈ঊιΣΒθ͉ྚ̺͕͂ͭ̓ະྶ̳́ȃུίυΐͿ ·Π͉́૽ࢥఉෝۚȪŪőŔȫळ༾̈́̓ͬဥ̞̀Ȃո͈ئ ࡄͤ৾ͅݪழ̞̳ͭ́͘ȃ ˍȫఉෝۚळ༾̥͈ͣΓυΠΣϋ૰ࠐ͈͒͂ࢹܥا ̷͈ພఠഎփ͈ٜ݅ྶ ȁΓυΠΣϋ͚ͬ܄κΦͺηϋయ৫͂ୈ૰͈ۛ͂۾Ⴒ̦ ঐഊ̯̤ͦ̀ͤȂΓυΠΣϋ૰ࠐ͈ܥෝٜଢ଼͉ਹါ̈́هఴ́ ̳ȃίυΐͿ·ΠςȜΘȜ͈ͣࡄݪȪ૰ࠐၑڠȫ́ ͉̭ͦ́͘ͅȂζ;Α ņŔ ळ༾̥ͣȂŪůġŷŪŵųŰ ́ΓυΠΣϋ૰ ࠐळ༾̵̯ͬͥاΏΑΞθ͈ࢹಃͬদ͙ȂडਞഎͅˍΑΞΛ ί̥ͣ̈́ͥ۰༒̈́ίυΠσ̵଼଼̱̯̭̱͂̀ۖͥ͂ͅ ̱̹͘ȃ࡛हȂ̭ͦͬဥ̞̀ΓυΠΣϋ૰ࠐ͈اည൵͈̱ ̩͙̳̞̀͛͘ͅૺͬݪࡄ̳ͥ۾ȃͅܡΓυΠΣϋ૰ࠐळ༾ ͅඅ։എͅอ࡛̳ͥ ŮŪŤųŰœŏł ͬ൳଼̳̭̱ͥ͂̀͜ͅ ̤ͤȂ࡛ह̷͈ܥෝ͞ພఠഎ̞̈́̀͛ૺͬݪࡄ̞̀̾ͅڬ ̳͘Ȫ४ચȫ ȃ̹͘Ȃζ;Α ņŔ ळ༾́ං̹ͣͦࡉͬΪΠ ŪőŔ ळ༾ͅ؊ဥ̱ȂŪőŔ ळ༾̥ͣΓυΠΣϋ૰ࠐͬࣞഽͅ ̵̯ͥاΏΑΞθ͈ٳอͬদ͙̞̳̀͘ȃ ˎȫୈ૰ۛۛ৪͈ ŪőŔ ळ༾ͬဥ̞̹ঊພఠࡄݪ ࡄهݪఴ 1）多能性幹細胞からのセロトニン神経への分化機構とその病 態的意義の解明 2）精神疾患患者の iPS 細胞を用いた分子病態研究 ड߃͈৽ါა 1. 2. 3. 4. Inoue T, et al. LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking. J Neurosci. 2014; 34:5927-37. Hoshina N, et al. Prococadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits. Neuron 2013; 78:839-54. Ohi K, et al. The p250GAP gene is associated with risk for schizophrenia and schizotypal personality trait. PLoS ONE 2012; 7:e35696. Shimada T, et al. A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells. J Neurochem. 2012; 122:81-93. ܖ๕ܿٳอξΣΛΠ ŪőŔ ࠬۯȆࠬסඉίυΐͿ·Π iPS Cell-based Research Project on Cardiovascular Toxicology 教授（兼任） 土井 健史 Professor Takefumi DOI 06-6879-8158 特任講師（常勤） 石本 憲司 Specially Appointed Associate Professor Kenji ISHIMOTO 06-6879-8166 特任助教（常勤） 今西悠基子 Specially Appointed Assistant Professor Yukiko IMANISHI 06-6879-3153 特任講師 石本憲司 [email protected] [email protected] [email protected] 特任助教 今西悠基子 ȁ֓ૺ͈ܿڠ༜̴ͣͩ͜ͅ۾Ȃ۪ܕ͉̤ۛࣽ̈́୶ ૺ੨࣭͈৽ါঘ֦͈̳֚̾́ȃহၷ͈ଇ௸̈́ٳอ̦བ ̞̳̦ͦ̀͘͘Ȃਲြ༹͈༷͉́հ̤͍͢ඉບث ́ཛྷఱ̈́ΑΠ͂শ̥̥̦ͤۼȂٳอષ͈ၙ௸̽̈́͂ٴ ̞͈̦࡛̀ͥે̳́ȃ জ̹̻͈ࡄݪ͉́ȂུίυΓᾺ̤̞ͅඅͅఉఱ̈́শ ۼȂႻႁȂΑΠͬါ̳ͥ൲ࡑͬȂŪőŔ ဇြاळ ༾̥ͣैୋ̱̹ழఘ́యఢ̳̭ͥ͂ͬ࿒എ̱͂̀ࡄݪ ͬই̱̹͛͘ȃߓఘഎ͉ͅȂڐಫ߿છ͈̈́̓֒ഥഎ ள֦ͬခ̳۪ͥܕۛͬΗȜΊΛΠ̱͂Ȃ Ȫˍȫ࠲ુ৪ ̤͍ۛ͢৪̥ͣ ŪőŔ ळ༾ͬैୋȂ Ȫˎȫळ༾͒اည ൵Ȃ Ȫˏȫࢥڠഎ༹ͬဥ̞ Ĵ ষࡓ͈ழఘͬैୋȂ Ȫːȫ ࣣاρͼήρςȜ̥ͣ༞सഞحȂ Ȫˑȫအழ ఘ͈सͅచ̳ͥ؊൞ບͬثঔ࣐̳ͥထ̳́ȃུࡄݪ ͤ͢ͅ૧̹̈́ບࠏثΏΑΞθ͈ࢹಃ̦ࢹಃ̯ͦͦ͊Ȃ ίυΓΑ͈ࠠഎ̈́࢘ၚ̩̥ࣺ̈́́ͤ͊ͥ͛ࡉ̦اȂ स͈ͤ͢ႉͅ߃̞൲ఠͬບܢ̧̦̭͂ͥ́ثఞ ̯̳ͦ͘ȃ̯ͣͅ൲ࡑၾ͈ఱ໙̈́ॉࡘ̦خෝ͂̈́ͤȂ ႃၑഎ͜ͅབ̱̞͂͘ࣉ̢̤̳̀ͤ͘ȃ ུίυΐͿ·Π଼͉ ijĶ ාഽͤ͢ٳই̱Ȃႉ؊ဥͬ ુͅැ൮ͅ౾̞̀ࡄͤ৾ͅݪழ̞̳ͭ́͘ȃ ġŪőŔ ဇြळ༾ȃζ;Α ŪőŔ ळ༾̥ͣळ༾ͅ اည൵̱Ȃ྾עஅȪષȫ̤͍͢ œŕĮőńœ ༹́ບ̱ث ̹̭͂ͧȂඅ։എഢৢ֦ঊ̜́ͥ ňłŕłĵ ̤͍͢ ŏŬŹijįĶȂਓੀ۾ႲΗϋΩ·̜́ͥϷĮŢŤŵŪůŪůȂťŦŴŮŪů ൝ ͈อ࡛̹ͬ͛ȃ̹͘ ŪőŔ ळ༾ैୋͅष̱൵ව̱̹֒ഥ ঊȪŐŤŵĵĭġŔŰŹijĭġŤĮŎźŤĭġŌŭŧĵȫ͈ อ ࡛ ͉ ͛ ̈́ ̥ ̽ ̹ ȃ ȪŚŶġŕįġńŪųŤġŋġijıIJĴĭġŎŪŬŪġŌįġŔŵŦŮġńŦŭŭŴġŕųŢůŴŭġŎŦťġijıIJijȫ ܖ๕ܿٳอξΣΛΠ ŪőŔ ෞ૰ࠐඉίυΐͿ·Π 教授（兼任） 橋本 均 特任准教授 中澤 敬信 特任助教 永安 一樹 Professor Specifically Appointed Associate Professor Specifically Appointed Assistant Professor iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology Hitoshi HASHIMOTO 06-6879-8180 Takanobu NAKAZAWA 06-6879-8182 Kazuki NAGAYASU 06-6879-8183 Fax 06-6879-8184 [email protected] [email protected] [email protected] 教 授 橋本 均 ȁΪΠ ŪőŔ ळ༾͈ ै ୋ ܿ ͬ ဥ ̞Ȃ ۛ৪͂࠲ુ৪͈ ŪőŔ ळ༾̷̸ͬͦ ͦෞ૰ࠐळ༾ͅ ̵̯̀اȂอో͞ ૰ࠐܥෝ̳ͬڛ ͥ ̭ ͂ ͅ ͢ ̽ ̀Ȃ ۛ৪͈ෞ̦͈̓͢ ̠̈́։ુͬ̽̀ ̞̥ٜͥͬྶ̳ͥ ௷̦̥ͤͬං̹̞ ఉෝۚळ༾ ȪņŔȆŪőŔȫ ̥͈ͣΓυΠΣϋ૰ࠐळ༾͈͂اا ͂ ࣉ ̢ ̀ ̞ ͘ ̳ȃ ༹̭͈̠༷̈́̽̀͢͢ͅȂୈ૰͈ۛอછࡔ֦͈൳͞ হၷ͈ດഎঊ͈ౝ॑ͬ࿒ঐ̱̳͘ȃ ȁୈ૰͈ۛພ֦̱͂̀Ȃ႕̢͊ఉ̩͈֒ഥ֦ঊ۪͂ޏ ါ֦̦ໝॠͅࡽैဥ̱̀อછ̳ͥب୰̈́̓Ȃఉତ͈ພ ֦ب୰̦া̯̞̳̦ͦ̀͘Ȃબ̯̹͈͉̩ͦ̈́͜Ȃ ̷͈ঊιΣΒθ͉ྚ̺͕͂ͭ̓ະྶ̳́ȃུίυΐͿ ·Π͉́૽ࢥఉෝۚȪŪőŔȫळ༾̈́̓ͬဥ̞̀Ȃո͈ئ ࡄͤ৾ͅݪழ̞̳ͭ́͘ȃ ˍȫఉෝۚळ༾̥͈ͣΓυΠΣϋ૰ࠐ͈͒͂ࢹܥا ̷͈ພఠഎփ͈ٜ݅ྶ ȁΓυΠΣϋ͚ͬ܄κΦͺηϋయ৫͂ୈ૰͈ۛ͂۾Ⴒ̦ ঐഊ̯̤ͦ̀ͤȂΓυΠΣϋ૰ࠐ͈ܥෝٜଢ଼͉ਹါ̈́هఴ́ ̳ȃίυΐͿ·ΠςȜΘȜ͈ͣࡄݪȪ૰ࠐၑڠȫ́ ͉̭ͦ́͘ͅȂζ;Α ņŔ ळ༾̥ͣȂŪůġŷŪŵųŰ ́ΓυΠΣϋ૰ ࠐळ༾̵̯ͬͥاΏΑΞθ͈ࢹಃͬদ͙ȂडਞഎͅˍΑΞΛ ί̥ͣ̈́ͥ۰༒̈́ίυΠσ̵଼଼̱̯̭̱͂̀ۖͥ͂ͅ ̱̹͘ȃ࡛हȂ̭ͦͬဥ̞̀ΓυΠΣϋ૰ࠐ͈اည൵͈̱ ̩͙̳̞̀͛͘ͅૺͬݪࡄ̳ͥ۾ȃͅܡΓυΠΣϋ૰ࠐळ༾ ͅඅ։എͅอ࡛̳ͥ ŮŪŤųŰœŏł ͬ൳଼̳̭̱ͥ͂̀͜ͅ ̤ͤȂ࡛ह̷͈ܥෝ͞ພఠഎ̞̈́̀͛ૺͬݪࡄ̞̀̾ͅڬ ̳͘Ȫ४ચȫ ȃ̹͘Ȃζ;Α ņŔ ळ༾́ං̹ͣͦࡉͬΪΠ ŪőŔ ळ༾ͅ؊ဥ̱ȂŪőŔ ळ༾̥ͣΓυΠΣϋ૰ࠐͬࣞഽͅ ̵̯ͥاΏΑΞθ͈ٳอͬদ͙̞̳̀͘ȃ ˎȫୈ૰ۛۛ৪͈ ŪőŔ ळ༾ͬဥ̞̹ঊພఠࡄݪ ࡄهݪఴ 1）多能性幹細胞からのセロトニン神経への分化機構とその病 態的意義の解明 2）精神疾患患者の iPS 細胞を用いた分子病態研究 ड߃͈৽ါა 1. 2. 3. 4. Inoue T, et al. LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking. J Neurosci. 2014; 34:5927-37. Hoshina N, et al. Prococadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits. Neuron 2013; 78:839-54. Ohi K, et al. The p250GAP gene is associated with risk for schizophrenia and schizotypal personality trait. PLoS ONE 2012; 7:e35696. Shimada T, et al. A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells. J Neurochem. 2012; 122:81-93. ܖ๕ܿٳอξΣΛΠ ŪőŔ ࠬۯȆࠬסඉίυΐͿ·Π iPS Cell-based Research Project on Cardiovascular Toxicology 教授（兼任） 土井 健史 Professor Takefumi DOI 06-6879-8158 特任講師（常勤） 石本 憲司 Specially Appointed Associate Professor Kenji ISHIMOTO 06-6879-8166 特任助教（常勤） 今西悠基子 Specially Appointed Assistant Professor Yukiko IMANISHI 06-6879-3153 特任講師 石本憲司 [email protected] [email protected] [email protected] 特任助教 今西悠基子 ȁ֓ૺ͈ܿڠ༜̴ͣͩ͜ͅ۾Ȃ۪ܕ͉̤ۛࣽ̈́୶ ૺ੨࣭͈৽ါঘ֦͈̳֚̾́ȃহၷ͈ଇ௸̈́ٳอ̦བ ̞̳̦ͦ̀͘͘Ȃਲြ༹͈༷͉́հ̤͍͢ඉບث ́ཛྷఱ̈́ΑΠ͂শ̥̥̦ͤۼȂٳอષ͈ၙ௸̽̈́͂ٴ ̞͈̦࡛̀ͥે̳́ȃ জ̹̻͈ࡄݪ͉́ȂུίυΓᾺ̤̞ͅඅͅఉఱ̈́শ ۼȂႻႁȂΑΠͬါ̳ͥ൲ࡑͬȂŪőŔ ဇြاळ ༾̥ͣैୋ̱̹ழఘ́యఢ̳̭ͥ͂ͬ࿒എ̱͂̀ࡄݪ ͬই̱̹͛͘ȃߓఘഎ͉ͅȂڐಫ߿છ͈̈́̓֒ഥഎ ள֦ͬခ̳۪ͥܕۛͬΗȜΊΛΠ̱͂Ȃ Ȫˍȫ࠲ુ৪ ̤͍ۛ͢৪̥ͣ ŪőŔ ळ༾ͬैୋȂ Ȫˎȫळ༾͒اည ൵Ȃ Ȫˏȫࢥڠഎ༹ͬဥ̞ Ĵ ষࡓ͈ழఘͬैୋȂ Ȫːȫ ࣣاρͼήρςȜ̥ͣ༞सഞحȂ Ȫˑȫအழ ఘ͈सͅచ̳ͥ؊൞ບͬثঔ࣐̳ͥထ̳́ȃུࡄݪ ͤ͢ͅ૧̹̈́ບࠏثΏΑΞθ͈ࢹಃ̦ࢹಃ̯ͦͦ͊Ȃ ίυΓΑ͈ࠠഎ̈́࢘ၚ̩̥ࣺ̈́́ͤ͊ͥ͛ࡉ̦اȂ स͈ͤ͢ႉͅ߃̞൲ఠͬບܢ̧̦̭͂ͥ́ثఞ ̯̳ͦ͘ȃ̯ͣͅ൲ࡑၾ͈ఱ໙̈́ॉࡘ̦خෝ͂̈́ͤȂ ႃၑഎ͜ͅབ̱̞͂͘ࣉ̢̤̳̀ͤ͘ȃ ུίυΐͿ·Π଼͉ ijĶ ාഽͤ͢ٳই̱Ȃႉ؊ဥͬ ુͅැ൮ͅ౾̞̀ࡄͤ৾ͅݪழ̞̳ͭ́͘ȃ ġŪőŔ ဇြळ༾ȃζ;Α ŪőŔ ळ༾̥ͣळ༾ͅ اည൵̱Ȃ྾עஅȪષȫ̤͍͢ œŕĮőńœ ༹́ບ̱ث ̹̭͂ͧȂඅ։എഢৢ֦ঊ̜́ͥ ňłŕłĵ ̤͍͢ ŏŬŹijįĶȂਓੀ۾ႲΗϋΩ·̜́ͥϷĮŢŤŵŪůŪůȂťŦŴŮŪů ൝ ͈อ࡛̹ͬ͛ȃ̹͘ ŪőŔ ळ༾ैୋͅष̱൵ව̱̹֒ഥ ঊȪŐŤŵĵĭġŔŰŹijĭġŤĮŎźŤĭġŌŭŧĵȫ͈ อ ࡛ ͉ ͛ ̈́ ̥ ̽ ̹ ȃ ȪŚŶġŕįġńŪųŤġŋġijıIJĴĭġŎŪŬŪġŌįġŔŵŦŮġńŦŭŭŴġŕųŢůŴŭġŎŦťġijıIJijȫ ܖ๕ܿٳอξΣΛΠ ŪőŔ ळ༾൲ఠίυΐͿ·Π iPS Cell-based Projects on Cell Transplantation and Cell Dynamics 特任教授（常勤） 大橋 一夫 Specifically Appointed Professor Kazuo OHASHI 06-6879-4091 [email protected] Hiroyuki TSUCHIYA (兼任) 教 授 大橋 一夫 ȁळ༾̥ͣ௫ͬܕͥȂ̷͉ͦȂ֓ڠႀ֖͈͈́ޭݪ هఴ̜́ͤȂυζϋ̜͏ͦͥΞȜζ̳́ȃ̶̈́Ȃ۴௫͉ ಸࠬۯၠȪྤȫ͂ఱ۪͈ͅۼպ౾̱̞͈̥̀ͥȂ̷ ͈ຈட͉̭̜͈̥̓ͥͅȃ۴௫̞̠͂௫ͬܕ႕̜̬ͅ ͥ͂Ȃ۴௫͉ષໜ໐ͅంह̳ͥఱ̧̈́ˍ͈̾௫̠̞͂ܕ ٽැ͈͂͜ͅࡄ͞ݪহၷٳอ̦̳̳̞̳̦͛ͣͦ̀͘Ȃ ఘ͈͂ܥෝ۾Ⴒ͞ఈ௫͈͂ܕႲࠈͬࣉ̢ͥ͂Ȃ̽͂͜ ুဇ̈́ࠁఠ͈۴௫Ȇळ༾̦ఘͅంह̱̞̞͈̥̀͜͜ ̵ͦͭ͘ȃ ȁུίυΐͿ·Π͉́Ȃ௫͞ܕळ༾̧͉̭̠̜͓̞ͥ͂ ̠ਲြ͈ٽැ̴͂ͣͩͦͅȂুဇ̈́อே́Ȃळ༾͂ࢊͤ ࣣ̞̦̈́ͣȂఘඤ̤̞̀ͅచયळ༾̦ܥෝ̞̥ͬͭ̈́ ̩อ̳ͬͥܞౝ̧̱̞̳॑̀͘ȃळ༾̦య৫͞౩ฒॲ ̢࣐ͬ͊হၷͬ࿒എ̱̹͂ழैୋ̳͂̈́ͤ͘ȃ̦ͭ ळ༾͈̦֚̾ࢹܥٜྶ̧́ͦ͊Ȃ̷͈ၔ༐̱̦ࢯ̦ ͭহၷ̧͍̳ࠫ̾͘ͅȃࡑ൲͈ఘඤ́చયळ༾͈ ̦ଷࢄ̧́ͦ͊Ȃ̷͈ͦͣळ༾ͬခ̳ͥ൲͉Ȃ̭ ̞̹̩ͦ́̈́̽͘͘ͅ૧̱̞࢘Ȇඉບܥ͈ثٛͬ ̳̩̱ͦ̀͘ރȃ ⓶ୗ䛷⏕╔⤌⧊䛧䛯䜲䞁䝇䝸䞁 ⏘⏕⣽⬊⩌ ᴟ⣽䝣䜯䜲䝞䞊ෆሸ䛷㧗ᶵ⬟ 䜢Ⓨ䛩䜛⫢⣽⬊䛸ᨭᣢ⣽⬊ ϱϬPŵ ϭϬϬPŵ ࡄهݪఴ 1）iPS 細胞分化過程と組織工学を融合した新規創薬基盤の開発 2）肝・膵・腎組織工学と遺伝子治療による新規治療法の開発 3）細胞膜と血液特性の関連を軸とした癌転移過程の解明 4）健康促進にむけた味覚・嗅覚再生の探索研究 ड߃͈৽ါა 1. Yamada M, Utoh R, Ohashi K, Tatsumi K, Yamato M, Okano T, Seki M. Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions. Biomaterials, 33: 8304-8315, 2012. 2. 大橋一夫 再生医療叢書 第５巻 肝細胞移植と肝組織工学「代謝系臓器の再生医療」 後藤満一、大橋一夫：編 朝倉書店 pp123-132, 2012. 3. Takayama K, Kawabata K, Inamura M, Ohashi K, Nagamoto Y, Okuno H, Yamaguchi Y, Tashiro K, Sakurai F, Hayakawa T, Kusuda-MF, Muzuguchi +&&$$7HQKDQFHUELQGLQJSURWHLQPHGLDWHGUHJXODWLRQRI7*)ȕUHFHSWRUH[SUHVVLRQGHWHUPLQHVKHSDWREODVWIDWHGHFLVLRQ'HYHORSPHQW 91-100, 2014. 4. Ohashi K, Okano T. Functional tissue engineering of the liver and islets. Anatomical Record, 297: 73-82, 2014. ႉࡄݪଔૺξΣΛΠ ֓ॸړ଼ίυΐͿ·Π Clinical Drug Development Unit Drug Discovery Sciences for Oligonucleotide Therapeutics 教 授 小比賀 聡 Professor 特任助教（常勤） 藤坂 朱紀 Specially Appointed Assistant Professor 助 教（兼任） 山本 剛史 Assistant Professor Satoshi OBIKA 06-6879-8200 Aki FUJISAKA 06-6879-8202 Tsuyoshi YAMAMOTO 06-6879-8202 [email protected] [email protected] [email protected] ̳ȃ̹͘Ȃࣞܥෝॸړঊͬဥ̞̹ດഎழ͈͒࢘ၚ എో͈ࡄͬݪଔૺ̱Ȃܖ๕ܿႁ͈ူ଼͞ࡄݪ৪ ଼͈֗৾ͤͅழ̞̳ͭ́͘ȃ ȁ͈֓ٳอ͉́Ȃȶ̩̳ͤȷ͈ਅͬౝ̳ࡄ̥ͣݪই ͤ͘Ȃ଼ࣣࡄݪȂΑ·ςȜΣϋΈ͂࡞ͩͦͥူळ༾͞ ൲ͬဥ̞̹͈࢘̈́̓ບ̦ͤ߫ث༐̱࣐ͩͦȂచય͂ ̳͈ͥۛহၷͅडഐ͈ࣣاͬࣆ̧ࣺ̞̳ͤͭ́͘ȃ ̭͈̠֚̈́͢Ⴒ͈ౝ॑എࡄ̱̀͂ض͈ࠫݪ༞ৗ̦ࡉ ̞̺̯ͦͥ͂Ȃষ͈̱̀͂ٴ༞ৗ͈ୋ௮൦͞ ৗບثȂհບ̓̈́ثȂႉদࡑ̫̹࢜ͅ൦̦̤̭ ̳̈́ͩͦ͘ȃ ȁŅŏł ͞ œŏł ͅैဥ̳ͥȶसȷͅȂ֓ॸړ̦̜ ̳ͤ͘ȃ̭͈֓ॸړ̤̫ͥͅࡄ́͜ݪ൳အً͈ ͬࠐ̞̳̀͘ȃ༷֚́Ȃॸړঊ̦ਲြ͈͓֓ͅ ঊၾ̦ఱ̧̞̭͂͞ഩͬكఝ̷͍̞̭͈̀ͥ͂̈́̓ ঊഎৗ͈̹͛Ȃ֓ॸړ͈͉́Ȃດഎழ͈͒ ో̦̱̱͊͊هఴ̳͂̈́ͤ͘ȃ̭͈အ̈́هఴ̱ͬ࣪Ȃ ͤ࢘͢ضഎ̈́࢘ͬࡉ̞̺̳̹͛ͅȂ֓ॸړͬດഎழ ͒࢘ၚഎͅో̵̯ͥࡄ̳̞࣐̦̀ͦͩ͘ݪȃ ȁ̭̠̞̹࡛̽ેͬ൩ِ̢̀͘ș͉ȂࣞτΑΞυȜσ ࠬછ൝ͬΗȜΊΛΠ̱̹ۛ͂ͺϋΙΓϋΑ֓ॸړ͈ ႉদࡑ̫̹࢜ͅࡄͬݪȂڠඤ͂͞۾ܥݪࡄ͈ٸڠ ͈ވ൳ࡄݪȂ͍ͅ൳̲ξΣΛΠ͈֓ॸړບڠشث őŋ ֓͞ॸړႉম őŋ ͈͂Ⴒࠈͤ͢ͅঔ̱̞̀͘ றୢఇਛ '1$ ৴ 51$ றୢఇ௬ఐ৾ ఏभੰෲ றୢఇभ়ਛଢ଼ যੵற॑৷ःञ ఇଢ଼ ৴ ৰୡपेॊ ఇभ௬ ॹॱشঋش५ಉ॑ ણ৷खञੰෲ သുཝ॑ઞढञ ఇ௬ ৴ றୢఇಏ෫ఇহ ࡄهݪఴ 1）高コレステロール血症をターゲットとしたアンチセンス医 薬の創成研究 2）核酸医薬の標的組織への効率的送達に関する研究
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