NO3、社会保険中央病院 肉芽腫性病変を認めた 移植腎生検 中京病院 Global Sclerosis/Glomeruli 0/7 診断 Hx: Focal granulomatous tubulointerstitial changes (i1,t2,g0,v0) Dx: Granulomatous arteriolitis and periglomerulitis, suspected 原病の再発(JRA, PN, JSG)疑い その他にサルコイドーシス,薬剤性間質性腎炎など. 拒絶反応は否定的である. NO4、京都府立医科大学 10ヶ月の間に著明な病理変化を 観察しえたMPGNの一例 京都府立医科大学 1回目生検 Global Sclerosis/Glomeruli 0/9 IgG C3 IgA C1q? IgM C4 診断 Dx: Diffuse endocapillary proliferative glomerulonephritis 2回目生検 Global Sclerosis/Glomeruli 0/27 IgG C1q IgA C3c IgM C3d κ λ 診断 Dx: Membranoproliferative glomerulonephritis with subendothelial crystal deposits R/O: Proliferative glomerulonephritis with monoclonal IgG deposits or Cryoglobulinemic glomerulonephritis and Crystal-storing histiocytosis (Plasma cell dyscrasia, suspected) 参考文献 ・Proliferative glomerulonephritis with monoclonal IgG deposits: A distinct entity mimicking immune-complex glomerulonephritis. H Samih, VD D’Agati et al. Kidney Int 65,85-96: 2004 ・Dysproteinemia-related nephropathy associated with crystal-storing histiocytosis MB Stokes, VD D’Agati et al Kidney International 70,597-602:2006 ・Crystal-Storing Histiocytosis Involving the Kidney on a Low-grade B cell Lymphoproliferative Disorder S. Sethi, HG Rennke et al. AJKD 39.183-188:2002 NO9、JR愛知厚生連海南病院 慢性腎炎経過中に全身性リンパ節 腫脹をきたした1例 海南病院 Global Sclerosis/Glomeruli 1/18 Hyaline vascular type 診断 #1. Glomerular microangiopathy and MPGN-like lesion associated with multicentric Castleman‘s disease of the lymph node #2. Interstitial eosinophilia, mild #3. Arteriolar hyalinosis, mild 参考文献 Multicentric castleman’s Disease Associated With Glomerular Microangiopathy and MPGN-Like Lesion: Does Vascular Endothelial Cell-Derived Growth Factor Play Causative or protective roles in renal injury? Aya Seida, Jun Wada et al. American Journal of kidney Disease 43(1),2004:E1 Castleman病の内皮障害におけるVEGFの関与 血中のVEGFの値は? 参考文献 • A spectrum of clinicopathological features of nephropathy associated with POEMS syndrome. Nephrol Dial Transplant 14, 2370-78:21999. NO3、社会保険中央病院 肉芽腫性病変を認めた 移植腎生検 中京病院 Global Sclerosis/Glomeruli 0/7 診断 Hx: Focal granulomatous tubulointerstitial changes (i1,t2,g0,v0) Dx: Granulomatous arteriolitis and periglomerulitis, suspected 原病の再発(JRA, PN, JSG)疑い その他にサルコイドーシス,薬剤性間質性腎炎など. 拒絶反応は否定的である. NO4、京都府立医科大学 10ヶ月の間に著明な病理変化を 観察しえたMPGNの一例 京都府立医科大学 1回目生検 Global Sclerosis/Glomeruli 0/9 IgG C3 IgA C1q? IgM C4 診断 Dx: Diffuse endocapillary proliferative glomerulonephritis 2回目生検 Global Sclerosis/Glomeruli 0/27 IgG C1q IgA C3c IgM C3d κ λ 診断 Dx: Membranoproliferative glomerulonephritis with subendothelial crystal deposits R/O: Proliferative glomerulonephritis with monoclonal IgG deposits or Cryoglobulinemic glomerulonephritis and Crystal-storing histiocytosis (Plasma cell dyscrasia, suspected) 参考文献 ・Proliferative glomerulonephritis with monoclonal IgG deposits: A distinct entity mimicking immune-complex glomerulonephritis. H Samih, VD D’Agati et al. Kidney Int 65,85-96: 2004 ・Dysproteinemia-related nephropathy associated with crystal-storing histiocytosis MB Stokes, VD D’Agati et al Kidney International 70,597-602:2006 ・Crystal-Storing Histiocytosis Involving the Kidney on a Low-grade B cell Lymphoproliferative Disorder S. Sethi, HG Rennke et al. AJKD 39.183-188:2002 NO9、JR愛知厚生連海南病院 慢性腎炎経過中に全身性リンパ節 腫脹をきたした1例 海南病院 Global Sclerosis/Glomeruli 1/18 Hyaline vascular type 診断 #1. Glomerular microangiopathy and MPGN-like lesion associated with multicentric Castleman‘s disease of the lymph node #2. Interstitial eosinophilia, mild #3. Arteriolar hyalinosis, mild 参考文献 Multicentric castleman’s Disease Associated With Glomerular Microangiopathy and MPGN-Like Lesion: Does Vascular Endothelial Cell-Derived Growth Factor Play Causative or protective roles in renal injury? Aya Seida, Jun Wada et al. American Journal of kidney Disease 43(1),2004:E1 Castleman病の内皮障害におけるVEGFの関与 血中のVEGFの値は? 参考文献 • A spectrum of clinicopathological features of nephropathy associated with POEMS syndrome. Nephrol Dial Transplant 14, 2370-78:21999.
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