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NO3、社会保険中央病院
肉芽腫性病変を認めた
移植腎生検
中京病院
Global Sclerosis/Glomeruli 0/7
診断
Hx: Focal granulomatous tubulointerstitial changes
(i1,t2,g0,v0)
Dx: Granulomatous arteriolitis and
periglomerulitis, suspected
原病の再発(JRA, PN, JSG)疑い
その他にサルコイドーシス,薬剤性間質性腎炎など.
拒絶反応は否定的である.
NO4、京都府立医科大学
10ヶ月の間に著明な病理変化を
観察しえたMPGNの一例
京都府立医科大学
1回目生検
Global Sclerosis/Glomeruli 0/9
IgG
C3
IgA
C1q?
IgM
C4
診断
Dx: Diffuse endocapillary proliferative
glomerulonephritis
2回目生検
Global Sclerosis/Glomeruli 0/27
IgG
C1q
IgA
C3c
IgM
C3d
κ
λ
診断
Dx: Membranoproliferative glomerulonephritis
with subendothelial crystal deposits
R/O: Proliferative glomerulonephritis with monoclonal IgG
deposits or Cryoglobulinemic glomerulonephritis
and Crystal-storing histiocytosis
(Plasma cell dyscrasia, suspected)
参考文献
・Proliferative glomerulonephritis with monoclonal IgG
deposits: A distinct entity mimicking immune-complex
glomerulonephritis. H Samih, VD D’Agati et al. Kidney Int
65,85-96: 2004
・Dysproteinemia-related nephropathy associated with
crystal-storing histiocytosis MB Stokes, VD D’Agati et al
Kidney International 70,597-602:2006
・Crystal-Storing Histiocytosis Involving the Kidney on a
Low-grade B cell Lymphoproliferative Disorder
S. Sethi, HG Rennke et al. AJKD 39.183-188:2002
NO9、JR愛知厚生連海南病院
慢性腎炎経過中に全身性リンパ節
腫脹をきたした1例
海南病院
Global Sclerosis/Glomeruli 1/18
Hyaline vascular type
診断
#1. Glomerular microangiopathy and
MPGN-like lesion associated with
multicentric Castleman‘s disease of
the lymph node
#2. Interstitial eosinophilia, mild
#3. Arteriolar hyalinosis, mild
参考文献
Multicentric castleman’s Disease Associated With Glomerular Microangiopathy
and MPGN-Like Lesion: Does Vascular Endothelial Cell-Derived Growth Factor
Play Causative or protective roles in renal injury?
Aya Seida, Jun Wada et al. American Journal of kidney Disease 43(1),2004:E1
Castleman病の内皮障害におけるVEGFの関与
血中のVEGFの値は?
参考文献
• A spectrum of clinicopathological features
of nephropathy associated with POEMS
syndrome. Nephrol Dial Transplant 14,
2370-78:21999.
NO3、社会保険中央病院
肉芽腫性病変を認めた
移植腎生検
中京病院
Global Sclerosis/Glomeruli 0/7
診断
Hx: Focal granulomatous tubulointerstitial changes
(i1,t2,g0,v0)
Dx: Granulomatous arteriolitis and
periglomerulitis, suspected
原病の再発(JRA, PN, JSG)疑い
その他にサルコイドーシス,薬剤性間質性腎炎など.
拒絶反応は否定的である.
NO4、京都府立医科大学
10ヶ月の間に著明な病理変化を
観察しえたMPGNの一例
京都府立医科大学
1回目生検
Global Sclerosis/Glomeruli 0/9
IgG
C3
IgA
C1q?
IgM
C4
診断
Dx: Diffuse endocapillary proliferative
glomerulonephritis
2回目生検
Global Sclerosis/Glomeruli 0/27
IgG
C1q
IgA
C3c
IgM
C3d
κ
λ
診断
Dx: Membranoproliferative glomerulonephritis
with subendothelial crystal deposits
R/O: Proliferative glomerulonephritis with monoclonal IgG
deposits or Cryoglobulinemic glomerulonephritis
and Crystal-storing histiocytosis
(Plasma cell dyscrasia, suspected)
参考文献
・Proliferative glomerulonephritis with monoclonal IgG
deposits: A distinct entity mimicking immune-complex
glomerulonephritis. H Samih, VD D’Agati et al. Kidney Int
65,85-96: 2004
・Dysproteinemia-related nephropathy associated with
crystal-storing histiocytosis MB Stokes, VD D’Agati et al
Kidney International 70,597-602:2006
・Crystal-Storing Histiocytosis Involving the Kidney on a
Low-grade B cell Lymphoproliferative Disorder
S. Sethi, HG Rennke et al. AJKD 39.183-188:2002
NO9、JR愛知厚生連海南病院
慢性腎炎経過中に全身性リンパ節
腫脹をきたした1例
海南病院
Global Sclerosis/Glomeruli 1/18
Hyaline vascular type
診断
#1. Glomerular microangiopathy and
MPGN-like lesion associated with
multicentric Castleman‘s disease of
the lymph node
#2. Interstitial eosinophilia, mild
#3. Arteriolar hyalinosis, mild
参考文献
Multicentric castleman’s Disease Associated With Glomerular Microangiopathy
and MPGN-Like Lesion: Does Vascular Endothelial Cell-Derived Growth Factor
Play Causative or protective roles in renal injury?
Aya Seida, Jun Wada et al. American Journal of kidney Disease 43(1),2004:E1
Castleman病の内皮障害におけるVEGFの関与
血中のVEGFの値は?
参考文献
• A spectrum of clinicopathological features
of nephropathy associated with POEMS
syndrome. Nephrol Dial Transplant 14,
2370-78:21999.