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氏名：礒良崇（イソヨシタカ）
昭和大学医学部卒（H10 年）
医学博士
昭和大学藤が丘リハビリテーション病院
内科・内部障害リハビリ部門准教授
心臓リハビリテーション室
医療連携推進室副室長
室長
資格：
内科認定医、循環器専門医、老年病専門医、脈管専門医
心臓リハビリテーション指導士
臨床研修指導医、身体障害者認定指定医（心臓機能障害）
所属学会：
日本内科学会、日本循環器学会、日本心臓リハビリテーション学会（評議員）、
日本腎臓リハビリテーション学会（代議員）、日本動脈硬化学会（評議員）、
日本脈管学会（評議員）、日本心不全学会（評議員）、日本再生医療学会（評
議員）、日本心臓病学会、日本老年医学会、日本呼吸ケア・リハビリテーショ
ン学会
活動内容：
＜診療＞
循環器内科、心血管リハビリテーション、動脈硬化、心不全、老年病
＜研究＞
間葉系幹細胞による心血管再生医療、血管・筋細胞の老化と再生、
心血管領域における Rehabilitation Science
受賞歴ほか：
平成１６年：昭和大学留学助成
平成１９年：昭和大学医学振興財団研究助成
平成２１年：日本再生医療学会第 1 回 YIA 臨床部門優秀賞
平成２５年：昭和大学医学部同窓会学術賞
平成２６年：昭和大学医学・医療振興財団医学研究助成（医療の実践）部門
競争的資金獲得：
２００８―２００９年度：文部科学省・日本学術振興会
科学研究費
若手研究 B：代表研究者
２０１０―２０１１年度：文部科学省・日本学術振興会
科学研究費
若手研究 B：代表研究者
２０１３―２０１５年度：文部科学省・日本学術振興会
科学研究費
基盤研究 C：代表研究者
論文業績
論文業績
☆原著論文
2014
・Usui S, Iso Y#, Sasai M, Mizukami T, Mori H, Watanabe T, Shioda S, Suzuki H.
Kisspeptin-10 induces endothelial cellular senescence and impaired endothelial
growth. Clin Sci (Lond). 2014 [Epub ahead of print]
・Usui S, Iso Y#, Sasai M, Mizukami T,Sato C,Kurata M,Spees JL, Umezawa A, Shioda S,
Suzuki H. Mesenchymal Stem Cells from Bone Marrow Enhance Neovascularization and
Stromal Cell Proliferation in Rat Ischemic Limb in the Early Phase after
Implantation. The Showa University Journal of Medical Sciences. 2014 (in press)
・Shoji M, Furuyama F, Yokota Y, Omori Y, Sato T, Tsunoda F, Iso YY, Koba S, Geshi
E, Katagiri T, Suzuki H, Kobayashi Y. IL-6 Mobilizes Bone Marrow-Derived Cells to
the Vascular Wall, Resulting in Neointima Formation via Inflammatory Effects.J
Atheroscler Thromb. 2014 [Epub ahead of print]
2013
・Iso Y, Rao K, Poole CN, Zaman T, Curril I, Sobel BE, Kajstura J, Anversa P, Spees
JL. Priming with ligands secreted by human stromal progenitor cells promotes grafts
of cardiac stem/progenitor cells after myocardial infarction. STEM CELLS 2013 [Epub
ahead of print].
・Fujimoto K, Hayashi A, Kamata Y, Ogawa A, Watanabe T, Ichikawa R, Iso Y, Koba S,
Kobayashi Y, Koyama T, Shichiri M. Circulating levels of human salusin-, a potent
hemodynamic and atherogenesis regulator. PLoS ONE 2013 [Epub ahead of print].
2012
・Iso Y, Yamaya S, Sato T, Poole CN, Isoyama K, Mimura M, Koba S, Kobayashi Y, Takeyama
Y, Spees JL, Suzuki H. Distinct Mobilization of Circulating CD271+ Mesenchymal
Progenitors from Hematopoietic Progenitors during Aging and after Myocardial
Infarction. Stem Cells Transl Med. 2012;1:462-8
2011 年
・Sato T*, Iso Y*, Uyama T, Kawachi K, Wakabayashi K, Omori Y, Soda T, Shoji M, Koba
S, Yokoyama SI, Fukuda N, Saito S, Katagiri T, Kobayashi Y, Takeyama Y, Umezawa A,
Suzuki H. Coronary vein infusion of multipotent stromal cells from bone marrow
preserves
cardiac
function
in
swine
ischemic
cardiomyopathy
via
enhanced
neovascularization. Lab Invest. 2011;91:553-64. *equal contribution.
・Kawachi K, Iso Y, Sato T, Wakabayashi K, Kobayashi Y, Takeyama Y, Suzuki H. Effects
of erythropoietin on angiogensis after myocardial infarction in porcine. Heart
Vessels 2011;27(1):79-88.
・Watanabe T, Sato K, Itoh F, Iso Y, Nagashima M, Hirano T, Shichiri MThe roles of
salusins in atherosclerosis and related cardiovascular diseases. J Am Soc Hypertens
2011;5:359-65.
2010 年
・Iso Y, Soda T, Sato T, Sato R, Kusuyama T, Omori Y, Shoji M, Koba S, Katagiri T,
Kobayashi Y, Suzuki H. Impact of implanted bone marrow progenitor cell composition
on limb salvage after cell implantation in patients with critical limb ischemia.
Atherosclerosis. 2010: 209:167-72.
・Mori H, Nakamachi T, Ohtaki H, Yofu S, Sato A, Endo K, Iso Y, Suzuki H, Takeyama
Y, Shintani N, Hashimoto H, Baba A, Shioda S. Cardioprotective effect of endogenous
pituitary
adenylate
cyclase-activating
polypeptide
on
Doxorubicin-induced
cardiomyopathy in mice. Circ J. 2010;74:1183-90.
・Ozawa T, Toba K, Suzuki H, Kato K, Iso Y, Akutsu Y, Kobayashi Y, Takeyama Y, Kobayashi
N, Yoshimura N, Akazawa K, Aizawa Y; EPO/AMI-I Pilot Study Researchers. Single-dose
intravenous administration of recombinant human erythropoietin is a promising
treatment for patients with acute myocardial infarction - randomized controlled pilot
trial of EPO/AMI-1 study -. Circ J. 2010;74:1415-23.
2009 年
・Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H,
Kobayashi Y, Miyazaki A, Hirano T. Preventive effects of heregulin-beta1 on macrophage
foam cell formation and atherosclerosis. Circ Res. 2009;105:500-10.
・Ban Y, Watanabe T, Suguro T, Matsuyama TA, Iso Y, Sakai T, Sato R, Idei T, Nakano
Y, Ota H, Miyazaki A, Kato N, Hirano T, Ban Y, Kobayashi Y. Increased plasma
urotensin-II and carotid atherosclerosis are associated with vascular dementia. J
Atheroscler Thromb. 2009;16:179-87.
・Suzuki H, Toba K, Kato K, Ozawa T, Tomosugi N, Higuchi M, Kusuyama T, Iso Y, Kobayashi
N, Yokoyama S, Fukuda N, Saitoh H, Akazawa K, Aizawa Y. Serum hepcidin-20 is elevated
during the acute phase of myocardial infarction. Tohoku J Exp Med. 2009;218:93-8.
2008 年
・Shoji M, Iso Y, Kusuyama T, Omori Y, Soda T, Tsunoda F, Sato T, Koba S, Geshi E,
Kobayashi Y, Katagiri T, Suzuki H. High-dose granulocyte-colony stimulating factor
promotes neointimal hyperplasia in the early phase and inhibits neointimal
hyperplasia in the late phase after vascular injury. Circ J. 2008;72:1885-93.
・Suzuki H, Kusuyama T, Sato R, Yokota Y, Tsunoda F, Sato T, Shoji M, Iso Y, Koba
S, Katagiri T. Elevation of matrix metalloproteinases and interleukin-6 in the culprit
coronary artery of myocardial infarction. Eur J Clin Invest. 2008;38:166-73.
・Sato T, Suzuki H, Kusuyama T, Omori Y, Soda T, Tsunoda F, Shoji M, Iso Y, Koba S,
Geshi E, Katagiri T, Kawachi K, Wakabayashi K, Takeyama Y. G-CSF after myocardial
infarction accelerates angiogenesis and reduces fibrosis in swine. Int J Cardiol.
2008;127:166-173.
2007 年
・Iso Y, Spees JL, Serrano C, Bakondi B, Pochampally R, Song YH, Sobel BE, Delafontaine
P, Prockop DJ. Multipotent human stromal cells improve cardiac function after
myocardial infarction in mice without long-term engraftment.
Biochem Biophys Res
Commun. 2007;354:700-6.
・Soda T, Suzuki H, Iso Y, Kusuyama T, Omori Y, Sato T, Shoji M, Koba S, Geshi E,
Katagiri T.
Bone marrow cells contribute to neointimal formation after stent
implantation in swine. Int J Cardiol. 2007;121:44-52.
・Kusuyama T, Suzuki H, Shoji M, Sato R, Omori Y, Soda T, Sato T, Iso Y, Koba S,
Geshi E, Katagiri T, Nakamachi T, Otaki H, Shioda S, Sekigawa K. Deficiency of the
TNF-alpha improves the recovery of blood perfusion in a mouse model of hindlimb
ischemia. J Showa Medical Associaion. 2007;67:126-33.
2006 年
・Iso Y, Suzuki H, Sato T, Shoji M, Shimizu N, Shibata M, Koba S, Geshi E, Katagiri
T.
Rho-kinase inhibitor suppressed restenosis in porcine coronary balloon
angioplasty. Int J Cardiol. 2006;106:103-10.
・Sato T, Suzuki H, Shibata M, Kusuyama T, Omori Y, Soda T, Shoji M, Iso Y, Koba S,
Geshi
E,
Katagiri
T,
Shioda
S,
Sekikawa
K.
Tumor-necrosis-factor-alpha-gene-deficient mice have improved cardiac function
through reduction of intercellular adhesion molecule-1 in myocardial infarction.
Circ J. 2006;70:1635-42.
・Suzuki H*, Iso Y*, Kusuyama T, Omori Y, Soda T, Sato T, Shoji M, Koba S, Geshi E,
Katagiri T.
Neutrophil and erythroblast regulate the effects of bone marrow cell
implantation. Eur J Clin Invest. 2006;36:65-6. * equal contribution.
・Suzuki H, Kusuyama T, Omori Y, Soda T, Tsunoda F, Sato T, Shoji M, Iso Y, Kondo
T, Koba S, Geshi E, Katagiri T. Inhibitory effect of candesartan cilexetil on left
ventricular remodeling after myocardial infarction. Int Heart J. 2006;47:715-25.
・Koba S, Hirano T, Ito Y, Tsunoda F, Yokota Y, Ban Y, Iso Y, Suzuki H, Katagiri T.
Significance of small dense low-density lipoprotein-cholesterol concentrations in
relation
to
the
severity
of
coronary
heart
diseases.
Atherosclerosis.
2006;189:206-14.
・Wakabayashi K, Suzuki H, Sato T, Iso Y, Katagiri T, Takeyama Y. Eplerenone suppresses
neointimal formation after coronary stent implantation in swine. Int J Cardiol.
2006;107:260-6.
2005 年
・Iso Y, Suzuki H, Sato T, Shoji M, Shibata M, Shimizu N, Koba S, Geshi E, Katagiri
T.
The mechanism of in-stent restenosis in radius stent: an experimental porcine
study. Circ J. 2005;69:481-7.
・Suzuki H, Sato R, Sato T, Shoji M, Iso Y, Kondo T, Shibata M, Koba S, Katagiri T.
Time-course of changes in the levels of interleukin 6 in acutely decompensated heart
failure. Int J Cardiol. 2005;100:415-20.
・Koba S, Tsunoda F, Hirano T, Iso Y, Suzuki H, Geshi E, Katagiri T. Postprandial
changes in LDL phenotypes in patients with myocardial infarction. Eur J Clin Invest.
2005;35:171-9.
2004 年
・Shoji M, Sata M, Fukuda D, Tanaka K, Sato T, Iso Y, Shibata M, Suzuki H, Koba S,
Geshi E, Katagiri T. Temporal and spatial characterization of cellular constituents
during neointimal hyperplasia after vascular injury: Potential contribution of
bone-marrow-derived progenitors to arterial remodeling.
Cardiovasc Pathol.
2004;13:306-12.
・Tsunoda F, Koba S, Hirano T, Ban Y, Iso Y, Suzuki H, Geshi E, Katagiri T. Association
between small dense low-density lipoprotein and postprandial accumulation of
triglyceride-rich remnant-like particles in normotriglyceridemic patients with
myocardial infarction. Circ J. 2004;68:1165-72.
・Shimizu N, Suzuki H, Wakabayashi K, Iso Y, Shibata M, Yorozuya M, Katagiri T, Takeyama
Y.
Expression of intercellular adhesion molecule-1 and vascular cell adhesion
molecule-1 in the pig coronary artery injury model: comparison of plain old balloon
angioplasty and stent implantation. J Cardiol. 2004;43:131-9.
2003 年
・Iso Y, Suzuki H, Sato T, Shoji M, Shibata M, Hamazaki Y, Koba S, Sakai T, Murakami
M, Geshi E, Katagiri T. Contribution of monocyte chemoattractant protein-1 and
c-fms/macrophage colony-stimulating factor receptor to coronary artery disease:
analysis of human coronary atherectomy specimens J Cardiol. 2003;42:29-36.
・Koba S, Hirano T, Murayama S, Kotani T, Tsunoda F, Iso Y, Ban Y, Kondo T, Suzuki
H, Katagiri T. Small dense LDL phenotype is associated with postprandial increases
of large VLDL and remnant-like particles in patients with acute myocardial infarction.
Atherosclerosis. 2003;170:131-40.
・Suzuki H, Murakami M, Shoji M, Iso Y, Kondo T, Shibata M, Ezumi H, Hamazaki Y, Koba
S, Katagiri T. Hepatocyte growth factor and vascular endothelial growth factor in
ischaemic heart disease. Coron Artery Dis. 2003;14:301-7.
2002 年
・Yorozuya M, Suzuki H, Iso Y, Shibata M, Nakatani M, Koba S, Murakami M, Katagiri
T, Takeyama Y. Comparison of the morphological changes of restenosis after the
implantation of various types of stents in a swine model. Coron Artery Dis.
2002;13:305-12.
☆総説
・Suzuki H, Iso Y. Clinical application of vascular regenerative therapy for peripheral
artery disease. Biomed Res Int. 2014 Epub ahead of print
・Iso Y, Watanabe T, Shoji M, Suzuki H. Stem/progenitor cell-based approach for
restenosis after percutaneous coronary intervention: Application of bone marrow
progenitors and future perspective. Translational Medicine 2012 S7-001
・Wakabayashi, K., Pakala, R., Watanabe, T., Mori, H., Iso Y. and Suzuki, H. Novel
technologies and future perspectives of drug-eluting stent. Translational Medicine
2012 S7-002
・Watanabe T, Sato K, Itoh F, Iso Y. Pathogenic involvement of heregulin-β(1) in
anti-atherogenesis. Regul Pept. 2012;175:11-4.
5: Watanabe, T., Sato, K., Itoh, F., Iso Y., Nagashima, M., Hirano, T., and Shichiri,
M. The roles of salusins in atherosclerosis and related cardiovascular diseases. J.
Am. Soc. Hypertens. 2011;5:359-365.
・礒
良崇、嶽山陽一：狭心症の経過と予後因子.「冠動脈疾患（下）」日本臨床２０１１
年１１月増刊号